The essence of asymptotic safety is the observation that nontrivial renormalization group fixed points can be used to generalize the procedure of perturbative renormalization. In an asymptotically safe theory, the couplings do not need to be small or tend to zero in the high energy limit but rather tend to finite values: they approach a "nontrivial UV fixed point." The running of the coupling constants, i.e. their scale dependence described by the renormalization group (RG), is thus special in its UV limit in the sense that all their dimensionless combinations remain finite. This suffices to avoid unphysical divergences, e.g. in scattering amplitudes. The requirement of a UV fixed point restricts the form of the bare action and the values of the bare coupling constants, which become predictions of the asymptotic safety program rather than inputs.
Steven Weinberg first proposed this idea as a possible approach to a quantum theory of gravity. But, alas, for gravity the standard procedure of perturbative renormalization fails catastrophically since Newton's constant, the relevant expansion parameter, has negative mass dimension, rendering general relativity perturbatively nonrenormalizable. This has driven the search for nonperturbative frameworks describing quantum gravity, including asymptotic safety which – in contrast to other approaches – is characterized by its use of standard quantum field theory methods (without depending on perturbative techniques, however). At the present time, there is accumulating evidence for a fixed point suitable for asymptotic safety, but a rigorous proof of its existence is still lacking. While this approach should not be counted out, it may turn out to have problems that cannot be solved. [Text mainly from Wikipedia.]